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STAB2

GENERAL INFORMATION

Gene name

 STAB2

Gene description

 Stabilin 2

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (spleen)
GTEx:Tissue enriched (spleen)
FANTOM5:Tissue enhanced (lymph node, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in sinusoidal endothelial cells of liver, spleen and lymph node.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA026871
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)

GENE INFORMATION

Gene name

 STAB2 (HGNC Symbol)

Synonyms

 DKFZP434E0321, FEEL-2, FELL, HARE, STAB-2

Description

 Stabilin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 103587273 - 103766727

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136011 (version 83.38)

Entrez gene

 55576

UniProt

 Q8WWQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WWQ8

Antibodypedia

 STAB2 antibodies

PROTEIN BROWSER
STAB2-001
STAB2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAB2-001
ENSP00000373539
ENST00000388887
Q8WWQ8 [Direct mapping]
Stabilin-2 190 kDa form stabilin-2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0005041 [low-density lipoprotein receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007155 [cell adhesion]
GO:0009897 [external side of plasma membrane]
GO:0010468 [regulation of gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030193 [regulation of blood coagulation]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030666 [endocytic vesicle membrane]
GO:0042742 [defense response to bacterium]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 2551 aa
277 kDa 		Yes 1
STAB2-006
ENSP00000446629
ENST00000552777
H0YHA5 [Direct mapping]
Stabilin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 135 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.