Cell atlas - USP44 - The Human Protein Atlas

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USP44

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Nucleoli fibrillar center

Human cell
	Microtubules
	Nucleoli

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GENERAL INFORMATION
Gene name	USP44
Gene description	Ubiquitin specific peptidase 44
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules & nucleoli (fibrillar center).
RNA cell category	Cell line enriched (NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved), Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA026543
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules & nucleoli (fibrillar center).

Main location

Nucleoli fibrillar center (approved), Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026543	A-431	Microtubules
	HPA026543	SH-SY5Y	Nucleoli fibrillar center
	HPA026543	SH-SY5Y	Microtubules
	HPA026543	U-2 OS	Nucleoli fibrillar center
	HPA026543	U-2 OS	Microtubules

GENE INFORMATION
Gene name	USP44 (HGNC Symbol)
Synonyms	FLJ14528
Description	Ubiquitin specific peptidase 44 (HGNC Symbol)
Entrez gene summary	Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q22
Chromosome location (bp)	95516560 - 95551490
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136014 (version 83.38)
Entrez gene	84101
UniProt	Q9H0E7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0E7
Antibodypedia	USP44 antibodies

PROTEIN BROWSER

USP44-001	USP44-002	USP44-003	USP44-004	USP44-005	USP44-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP44-001 ENSP00000258499 ENST00000258499	Q9H0E7 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 44 A0A024RBD7 [Target identity:100%; Query identity:100%] Ubiquitin carboxyl-terminal hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007067 [mitotic nuclear division] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0060564 [negative regulation of APC-Cdc20 complex activity] GO:0090231 [regulation of spindle checkpoint] GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint] Show all	712 aa 81.2 kDa	No	0
USP44-002 ENSP00000442629 ENST00000537435	Q9H0E7 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 44 A0A024RBD7 [Target identity:100%; Query identity:100%] Ubiquitin carboxyl-terminal hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007067 [mitotic nuclear division] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0060564 [negative regulation of APC-Cdc20 complex activity] GO:0090231 [regulation of spindle checkpoint] GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint] Show all	712 aa 81.2 kDa	No	0
USP44-003 ENSP00000448670 ENST00000552440	F8VRI7 [Direct mapping] Ubiquitinyl hydrolase 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	496 aa 56.5 kDa	No	0
USP44-004 ENSP00000376806 ENST00000393091	Q9H0E7 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 44 A0A024RBD7 [Target identity:100%; Query identity:100%] Ubiquitin carboxyl-terminal hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007067 [mitotic nuclear division] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0060564 [negative regulation of APC-Cdc20 complex activity] GO:0090231 [regulation of spindle checkpoint] GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint] Show all	712 aa 81.2 kDa	No	0
USP44-005 ENSP00000449635 ENST00000549639	F8VVD6 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 44 Show all	Predicted intracellular proteins Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0008270 [zinc ion binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	111 aa 12.7 kDa	No	0
USP44-007 ENSP00000448601 ENST00000551837	F8VRW0 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 44 Show all	Predicted intracellular proteins Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0008270 [zinc ion binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	164 aa 18.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.