Expression of CKAP4 in cancer - Summary - The Human Protein Atlas

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CKAP4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CKAP4
Gene description	Cytoskeleton-associated protein 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA000278 , HPA000792
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000278	HPA000792

GENE INFORMATION
Gene name	CKAP4 (HGNC Symbol)
Synonyms	CLIMP-63, ERGIC-63, P63
Description	Cytoskeleton-associated protein 4 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	106237877 - 106304279
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136026 (version 83.38)
Entrez gene	10970
UniProt	Q07065 (UniProt - Evidence at protein level)
neXtProt	NX_Q07065
Antibodypedia	CKAP4 antibodies

PROTEIN BROWSER

CKAP4-001	CKAP4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKAP4-001 ENSP00000367265 ENST00000378026	Q07065 [Direct mapping] Cytoskeleton-associated protein 4 A0A024RBH2 [Target identity:100%; Query identity:100%] Cytoskeleton-associated protein 4, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	602 aa 66 kDa	No	1
CKAP4-006 ENSP00000449240 ENST00000553039	F8VVU0 [Direct mapping] Cytoskeleton-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 2.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.