Expression of DRAM1 in cancer - Summary - The Human Protein Atlas

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DRAM1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	DRAM1
Gene description	DNA-damage regulated autophagy modulator 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	DRAM1 (HGNC Symbol)
Synonyms	DRAM, FLJ11259
Description	DNA-damage regulated autophagy modulator 1 (HGNC Symbol)
Entrez gene summary	This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q23.2
Chromosome location (bp)	101877351 - 102012130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136048 (version 83.38)
Entrez gene	55332
UniProt	Q8N682 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N682
Antibodypedia	DRAM1 antibodies

PROTEIN BROWSER

DRAM1-001	DRAM1-002	DRAM1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DRAM1-001 ENSP00000258534 ENST00000258534	Q8N682 [Direct mapping] DNA damage-regulated autophagy modulator protein 1 A0A024RBF9 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0016021 [integral component of membrane] Show all	238 aa 26.3 kDa	No	6
DRAM1-002 ENSP00000445827 ENST00000544152	Q8N682 [Direct mapping] DNA damage-regulated autophagy modulator protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0016021 [integral component of membrane] Show all	128 aa 14 kDa	No	3
DRAM1-006 ENSP00000447906 ENST00000549066	H0YHV0 [Direct mapping] DNA damage-regulated autophagy modulator protein 1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	53 aa 5.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.