Tissue expression of DRAM1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DRAM1
Gene description	DNA-damage regulated autophagy modulator 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DRAM1 (HGNC Symbol)
Synonyms	DRAM, FLJ11259
Description	DNA-damage regulated autophagy modulator 1 (HGNC Symbol)
Entrez gene summary	This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q23.2
Chromosome location (bp)	101877351 - 102012130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136048 (version 83.38)
Entrez gene	55332
UniProt	Q8N682 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N682
Antibodypedia	DRAM1 antibodies

PROTEIN BROWSER

DRAM1-001	DRAM1-002	DRAM1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DRAM1-001 ENSP00000258534 ENST00000258534	Q8N682 [Direct mapping] DNA damage-regulated autophagy modulator protein 1 A0A024RBF9 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0016021 [integral component of membrane] Show all	238 aa 26.3 kDa	No	6
DRAM1-002 ENSP00000445827 ENST00000544152	Q8N682 [Direct mapping] DNA damage-regulated autophagy modulator protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0016021 [integral component of membrane] Show all	128 aa 14 kDa	No	3
DRAM1-006 ENSP00000447906 ENST00000549066	H0YHV0 [Direct mapping] DNA damage-regulated autophagy modulator protein 1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	53 aa 5.9 kDa	No	0