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RNASEH2B

GENERAL INFORMATION

Gene name

 RNASEH2B

Gene description

 Ribonuclease H2, subunit B

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA040084
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RNASEH2B (HGNC Symbol)

Synonyms

 AGS2, DLEU8, FLJ11712

Description

 Ribonuclease H2, subunit B (HGNC Symbol)

Entrez gene summary

 RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]

Chromosome

 13

Cytoband

 q14.3

Chromosome location (bp)

 50909678 - 50973745

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136104 (version 83.38)

Entrez gene

 79621

UniProt

 Q5TBB1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5TBB1

Antibodypedia

 RNASEH2B antibodies

PROTEIN BROWSER
RNASEH2B-001
RNASEH2B-008
RNASEH2B-009
RNASEH2B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNASEH2B-001
ENSP00000337623
ENST00000336617
Q5TBB1 [Direct mapping]
Ribonuclease H2 subunit B
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006401 [RNA catabolic process]
GO:0009259 [ribonucleotide metabolic process]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0032299 [ribonuclease H2 complex]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:2000001 [regulation of DNA damage checkpoint]
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 312 aa
35.1 kDa 		No 0
RNASEH2B-008
ENSP00000482701
ENST00000616907
A0A087WZJ6 [Direct mapping]
Ribonuclease H2 subunit B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
 84 aa
9.3 kDa 		No 0
RNASEH2B-009
ENSP00000389877
ENST00000422660
Q5TBB1 [Direct mapping]
Ribonuclease H2 subunit B
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006401 [RNA catabolic process]
GO:0032299 [ribonuclease H2 complex]
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 257 aa
29 kDa 		No 0
RNASEH2B-201
ENSP00000481236
ENST00000611510
A0A087WXR7 [Direct mapping]
Ribonuclease H2 subunit B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
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 332 aa
37.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.