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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SPRY2
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SPRY2

Gene description

Sprouty RTK signaling antagonist 2

Protein class

Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AN3-CA)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB037205
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB037205

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant cells showed weak to moderate cytoplasmic staining. A few cases of colorectal, ovarian, endometrial, pancreatic and liver cancers displayed strong positivity. Malignant lymphomas and skin cancers were mainly negative.

GENE INFORMATION

Gene name

SPRY2 (HGNC Symbol)

Synonyms

hSPRY2

Description

Sprouty RTK signaling antagonist 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q31.1

Chromosome location (bp)

80335976 - 80340951

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136158 (version 83.38)

Entrez gene

10253

UniProt

O43597 (UniProt - Evidence at protein level)

neXtProt

NX_O43597

Antibodypedia

SPRY2 antibodies

PROTEIN BROWSER

SPRY2-001
SPRY2-002
SPRY2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPRY2-001
ENSP00000366308
ENST00000377104
O43597 [Direct mapping]
Protein sprouty homolog 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010628 [positive regulation of gene expression]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0031345 [negative regulation of cell projection organization]
GO:0032587 [ruffle membrane]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045595 [regulation of cell differentiation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
315 aa
34.7 kDa
No 1
SPRY2-002
ENSP00000366306
ENST00000377102
O43597 [Direct mapping]
Protein sprouty homolog 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007605 [sensory perception of sound]
GO:0008285 [negative regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010628 [positive regulation of gene expression]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0030324 [lung development]
GO:0031345 [negative regulation of cell projection organization]
GO:0032587 [ruffle membrane]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034260 [negative regulation of GTPase activity]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045165 [cell fate commitment]
GO:0045595 [regulation of cell differentiation]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0051387 [negative regulation of neurotrophin TRK receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060425 [lung morphogenesis]
GO:0060437 [lung growth]
GO:0060449 [bud elongation involved in lung branching]
GO:0060541 [respiratory system development]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
315 aa
34.7 kDa
No 1
SPRY2-201
ENSP00000439027
ENST00000540649
A0A0A0MTG9 [Direct mapping]
Protein sprouty homolog 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007275 [multicellular organismal development]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045595 [regulation of cell differentiation]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
Show all
353 aa
39.2 kDa
No 1

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