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SPRY2

GENERAL INFORMATION

Gene name

 SPRY2

Gene description

 Sprouty RTK signaling antagonist 2

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB037205
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010203040506070TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin010203040RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120140Tags Per Million

GENE INFORMATION

Gene name

 SPRY2 (HGNC Symbol)

Synonyms

 hSPRY2

Description

 Sprouty RTK signaling antagonist 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q31.1

Chromosome location (bp)

 80335976 - 80340951

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136158 (version 83.38)

Entrez gene

 10253

UniProt

 O43597 (UniProt - Evidence at protein level)

neXtProt

 NX_O43597

Antibodypedia

 SPRY2 antibodies

PROTEIN BROWSER
SPRY2-001
SPRY2-002
SPRY2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPRY2-001
ENSP00000366308
ENST00000377104
O43597 [Direct mapping]
Protein sprouty homolog 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010628 [positive regulation of gene expression]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0031345 [negative regulation of cell projection organization]
GO:0032587 [ruffle membrane]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045595 [regulation of cell differentiation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 315 aa
34.7 kDa 		No 1
SPRY2-002
ENSP00000366306
ENST00000377102
O43597 [Direct mapping]
Protein sprouty homolog 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007605 [sensory perception of sound]
GO:0008285 [negative regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010628 [positive regulation of gene expression]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0030324 [lung development]
GO:0031345 [negative regulation of cell projection organization]
GO:0032587 [ruffle membrane]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034260 [negative regulation of GTPase activity]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045165 [cell fate commitment]
GO:0045595 [regulation of cell differentiation]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0051387 [negative regulation of neurotrophin TRK receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060425 [lung morphogenesis]
GO:0060437 [lung growth]
GO:0060449 [bud elongation involved in lung branching]
GO:0060541 [respiratory system development]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 315 aa
34.7 kDa 		No 1
SPRY2-201
ENSP00000439027
ENST00000540649
A0A0A0MTG9 [Direct mapping]
Protein sprouty homolog 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007275 [multicellular organismal development]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045595 [regulation of cell differentiation]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
Show all
 353 aa
39.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.