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DBNL

GENERAL INFORMATION

Gene name

 DBNL

Gene description

 Drebrin-like

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in several different tissue types, most abundant in lymphoid organs.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA020265 , HPA027735
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA020265
HPA027735

GENE INFORMATION

Gene name

 DBNL (HGNC Symbol)

Synonyms

 HIP-55, SH3P7

Description

 Drebrin-like (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44044640 - 44069456

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136279 (version 83.38)

Entrez gene

 28988

UniProt

 Q9UJU6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJU6

Antibodypedia

 DBNL antibodies

PROTEIN BROWSER
DBNL-001
DBNL-003
DBNL-004
DBNL-005
DBNL-009
DBNL-017
DBNL-018
DBNL-019
DBNL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DBNL-001
ENSP00000411701
ENST00000448521
Q9UJU6 [Direct mapping]
Drebrin-like protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0002250 [adaptive immune response]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007257 [activation of JUN kinase activity]
GO:0007416 [synapse assembly]
GO:0008047 [enzyme activator activity]
GO:0012501 [programmed cell death]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071800 [podosome assembly]
GO:0097178 [ruffle assembly]
Show all
 430 aa
48.2 kDa 		No 0
DBNL-003
ENSP00000416421
ENST00000456905
Q9UJU6 [Direct mapping]
Drebrin-like protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0002250 [adaptive immune response]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007257 [activation of JUN kinase activity]
GO:0007416 [synapse assembly]
GO:0008047 [enzyme activator activity]
GO:0012501 [programmed cell death]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071800 [podosome assembly]
GO:0097178 [ruffle assembly]
Show all
 382 aa
43 kDa 		No 0
DBNL-004
ENSP00000415173
ENST00000440166
Q9UJU6 [Direct mapping]
Drebrin-like protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0002250 [adaptive immune response]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007257 [activation of JUN kinase activity]
GO:0007416 [synapse assembly]
GO:0008047 [enzyme activator activity]
GO:0012501 [programmed cell death]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071800 [podosome assembly]
GO:0097178 [ruffle assembly]
Show all
 327 aa
37.1 kDa 		No 0
DBNL-005
ENSP00000405343
ENST00000452943
B4DDD6 [Direct mapping]
Drebrin-like protein; cDNA FLJ59450, highly similar to Drebrin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006898 [receptor-mediated endocytosis]
GO:0007416 [synapse assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0097178 [ruffle assembly]
Show all
 406 aa
45.7 kDa 		No 0
DBNL-009
ENSP00000398931
ENST00000432854
H0Y5J4 [Direct mapping]
Drebrin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006898 [receptor-mediated endocytosis]
GO:0007416 [synapse assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0097178 [ruffle assembly]
Show all
 359 aa
40.2 kDa 		No 0
DBNL-017
ENSP00000397855
ENST00000452661
H7C111 [Direct mapping]
Drebrin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006898 [receptor-mediated endocytosis]
GO:0007416 [synapse assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0097178 [ruffle assembly]
Show all
 138 aa
15.1 kDa 		No 0
DBNL-018
ENSP00000419992
ENST00000494774
Q9UJU6 [Direct mapping]
Drebrin-like protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0002250 [adaptive immune response]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007257 [activation of JUN kinase activity]
GO:0007416 [synapse assembly]
GO:0008047 [enzyme activator activity]
GO:0012501 [programmed cell death]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071800 [podosome assembly]
GO:0097178 [ruffle assembly]
Show all
 431 aa
48.3 kDa 		No 0
DBNL-019
ENSP00000417653
ENST00000468694
Q9UJU6 [Direct mapping]
Drebrin-like protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0002250 [adaptive immune response]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007257 [activation of JUN kinase activity]
GO:0007416 [synapse assembly]
GO:0008022 [protein C-terminus binding]
GO:0008047 [enzyme activator activity]
GO:0012501 [programmed cell death]
GO:0014069 [postsynaptic density]
GO:0016601 [Rac protein signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071800 [podosome assembly]
GO:0097178 [ruffle assembly]
Show all
 439 aa
49 kDa 		No 0
DBNL-201
ENSP00000417749
ENST00000490734
Q9UJU6 [Direct mapping]
Drebrin-like protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0002250 [adaptive immune response]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007257 [activation of JUN kinase activity]
GO:0007416 [synapse assembly]
GO:0008047 [enzyme activator activity]
GO:0012501 [programmed cell death]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071800 [podosome assembly]
GO:0097178 [ruffle assembly]
Show all
 336 aa
38 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.