Expression of TTC5 in cancer - Summary - The Human Protein Atlas

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TTC5

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TTC5
Gene description	Tetratricopeptide repeat domain 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA045008
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045008

GENE INFORMATION
Gene name	TTC5 (HGNC Symbol)
Synonyms	Strap
Description	Tetratricopeptide repeat domain 5 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20256558 - 20305994
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136319 (version 83.38)
Entrez gene	91875
UniProt	Q8N0Z6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N0Z6
Antibodypedia	TTC5 antibodies

PROTEIN BROWSER

TTC5-001	TTC5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTC5-001 ENSP00000258821 ENST00000258821	Q8N0Z6 [Direct mapping] Tetratricopeptide repeat protein 5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	440 aa 48.9 kDa	No	0
TTC5-005 ENSP00000451259 ENST00000553828	G3V3I6 [Direct mapping] Tetratricopeptide repeat protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.