Cell atlas - MTHFS - The Human Protein Atlas

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MTHFS

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MTHFS
Gene description	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA054177
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054177	A-431	Cytosol
	HPA054177	MCF7	Cytosol
	HPA054177	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MTHFS (HGNC Symbol)
Synonyms	HsT19268
Description	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	79833585 - 79897379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136371 (version 83.38)
Entrez gene	10588
UniProt	P49914 (UniProt - Evidence at protein level)
neXtProt	NX_P49914
Antibodypedia	MTHFS antibodies

PROTEIN BROWSER

MTHFS-001	MTHFS-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTHFS-001 ENSP00000258874 ENST00000258874	P49914 [Direct mapping] 5-formyltetrahydrofolate cyclo-ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005542 [folic acid binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006536 [glutamate metabolic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0015942 [formate metabolic process] GO:0030272 [5-formyltetrahydrofolate cyclo-ligase activity] GO:0035999 [tetrahydrofolate interconversion] GO:0046653 [tetrahydrofolate metabolic process] GO:0046657 [folic acid catabolic process] GO:0046872 [metal ion binding] Show all	203 aa 23.3 kDa	No	0
MTHFS-007 ENSP00000489076 ENST00000559722		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		232 aa 26.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.