Expression of MTHFS in cancer - Summary - The Human Protein Atlas

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MTHFS

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MTHFS
Gene description	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 2 antibodies. HPA008067 , HPA054177
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable), renal cancer (favourable) and glioma (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008067	HPA054177

GENE INFORMATION
Gene name	MTHFS (HGNC Symbol)
Synonyms	HsT19268
Description	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	79833585 - 79897379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136371 (version 83.38)
Entrez gene	10588
UniProt	P49914 (UniProt - Evidence at protein level)
neXtProt	NX_P49914
Antibodypedia	MTHFS antibodies

PROTEIN BROWSER

MTHFS-001	MTHFS-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTHFS-001 ENSP00000258874 ENST00000258874	P49914 [Direct mapping] 5-formyltetrahydrofolate cyclo-ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005542 [folic acid binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006536 [glutamate metabolic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0015942 [formate metabolic process] GO:0030272 [5-formyltetrahydrofolate cyclo-ligase activity] GO:0035999 [tetrahydrofolate interconversion] GO:0046653 [tetrahydrofolate metabolic process] GO:0046657 [folic acid catabolic process] GO:0046872 [metal ion binding] Show all	203 aa 23.3 kDa	No	0
MTHFS-007 ENSP00000489076 ENST00000559722		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		232 aa 26.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.