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NMT1

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GENERAL INFORMATION

Gene name

 NMT1

Gene description

 N-myristoyltransferase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA022949
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (approved), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA022949 A-431 Plasma membrane
Cytosol
HPA022949 U-2 OS Plasma membrane
Cytosol
HPA022949 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 NMT1 (HGNC Symbol)

Synonyms

 NMT

Description

 N-myristoyltransferase 1 (HGNC Symbol)

Entrez gene summary

 Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 45051610 - 45109016

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136448 (version 83.38)

Entrez gene

 4836

UniProt

 P30419 (UniProt - Evidence at protein level)

neXtProt

 NX_P30419

Antibodypedia

 NMT1 antibodies

PROTEIN BROWSER
NMT1-001
NMT1-007
NMT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NMT1-001
ENSP00000468424
ENST00000592782
P30419 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006499 [N-terminal protein myristoylation]
GO:0006915 [apoptotic process]
GO:0007603 [phototransduction, visible light]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016032 [viral process]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0018008 [N-terminal peptidyl-glycine N-myristoylation]
GO:0019107 [myristoyltransferase activity]
GO:0019898 [extrinsic component of membrane]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030054 [cell junction]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 496 aa
56.8 kDa 		No 0
NMT1-007
ENSP00000466827
ENST00000592654
K7EN82 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0006499 [N-terminal protein myristoylation]
GO:0015629 [actin cytoskeleton]
GO:0030054 [cell junction]
Show all
 72 aa
8.2 kDa 		No 0
NMT1-201
ENSP00000258960
ENST00000258960
P30419 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006499 [N-terminal protein myristoylation]
GO:0006915 [apoptotic process]
GO:0007603 [phototransduction, visible light]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016032 [viral process]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0018008 [N-terminal peptidyl-glycine N-myristoylation]
GO:0019898 [extrinsic component of membrane]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030054 [cell junction]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 496 aa
56.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.