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NMT1

GENERAL INFORMATION

Gene name

 NMT1

Gene description

 N-myristoyltransferase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA022949 , HPA022963
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA022949
HPA022963

GENE INFORMATION

Gene name

 NMT1 (HGNC Symbol)

Synonyms

 NMT

Description

 N-myristoyltransferase 1 (HGNC Symbol)

Entrez gene summary

 Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 45051610 - 45109016

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136448 (version 83.38)

Entrez gene

 4836

UniProt

 P30419 (UniProt - Evidence at protein level)

neXtProt

 NX_P30419

Antibodypedia

 NMT1 antibodies

PROTEIN BROWSER
NMT1-001
NMT1-007
NMT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NMT1-001
ENSP00000468424
ENST00000592782
P30419 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006499 [N-terminal protein myristoylation]
GO:0006915 [apoptotic process]
GO:0007603 [phototransduction, visible light]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016032 [viral process]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0018008 [N-terminal peptidyl-glycine N-myristoylation]
GO:0019107 [myristoyltransferase activity]
GO:0019898 [extrinsic component of membrane]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030054 [cell junction]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
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 496 aa
56.8 kDa 		No 0
NMT1-007
ENSP00000466827
ENST00000592654
K7EN82 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0006499 [N-terminal protein myristoylation]
GO:0015629 [actin cytoskeleton]
GO:0030054 [cell junction]
Show all
 72 aa
8.2 kDa 		No 0
NMT1-201
ENSP00000258960
ENST00000258960
P30419 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006499 [N-terminal protein myristoylation]
GO:0006915 [apoptotic process]
GO:0007603 [phototransduction, visible light]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016032 [viral process]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0018008 [N-terminal peptidyl-glycine N-myristoylation]
GO:0019898 [extrinsic component of membrane]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030054 [cell junction]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 496 aa
56.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.