Cell atlas - RPS6KC1 - The Human Protein Atlas

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RPS6KC1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Endosomes
	Lysosomes

Human cell
	Cytosol
	Vesicles

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GENERAL INFORMATION
Gene name	RPS6KC1
Gene description	Ribosomal protein S6 kinase, 52kDa, polypeptide 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endosome & lysosome. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endosomes (validated), Lysosomes (validated)
Additional location	In addition localized to the Cytosol (validated)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA026531 , HPA031565
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endosome & lysosome. In addition localized to the cytosol.

Main location

Endosomes (validated), Lysosomes (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA026531	A-431	Vesicles
HPA026531	U-2 OS	Vesicles
HPA026531	U-251 MG	Vesicles
HPA026531	U-251 MG	Cytosol
HPA031565	A-431	No staining
HPA031565	U-2 OS	Endosomes
HPA031565	U-2 OS	Lysosomes
HPA031565	U-251 MG	Endosomes
HPA031565	U-251 MG	Lysosomes

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA031565	U-2 OS	Image	RPS6KC1 localizes to a subcompartment of retromers, as it does not completely co-localizes with the retromer marker VPS26A in a retromer.


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA031565	U-2 OS	Image	RPS6KC1 localizes to lysosomes, as it partially co-localizes with the lysosomal marker LAMP1/CD107a.

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000089872 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA026531	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	RPS6KC1 (HGNC Symbol)
Synonyms	humS6PKh1
Description	Ribosomal protein S6 kinase, 52kDa, polypeptide 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q32.3
Chromosome location (bp)	213051233 - 213274773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136643 (version 83.38)
Entrez gene	26750
UniProt	Q96S38 (UniProt - Evidence at protein level)
neXtProt	NX_Q96S38
Antibodypedia	RPS6KC1 antibodies

PROTEIN BROWSER

RPS6KC1-001	RPS6KC1-002	RPS6KC1-201	RPS6KC1-202	RPS6KC1-203	RPS6KC1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS6KC1-001 ENSP00000355927 ENST00000366960	Q96S38 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0035091 [phosphatidylinositol binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	1066 aa 118.7 kDa	No	0
RPS6KC1-002 ENSP00000355926 ENST00000366959	Q96S38 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0035091 [phosphatidylinositol binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	1054 aa 117.3 kDa	No	0
RPS6KC1-201 ENSP00000439282 ENST00000543354	F6RJM5 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	885 aa 97.9 kDa	No	0
RPS6KC1-202 ENSP00000442306 ENST00000543470	F5H7T0 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0043231 [intracellular membrane-bounded organelle] Show all	854 aa 94.5 kDa	No	0
RPS6KC1-203 ENSP00000483873 ENST00000614059	F5H7T0 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0043231 [intracellular membrane-bounded organelle] Show all	854 aa 94.5 kDa	No	0
RPS6KC1-204 ENSP00000484471 ENST00000615329	A0A087X1U5 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	601 aa 66.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.