Expression of RPS6KC1 in cancer - Summary - The Human Protein Atlas

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RPS6KC1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RPS6KC1
Gene description	Ribosomal protein S6 kinase, 52kDa, polypeptide 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA026531
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026531

GENE INFORMATION
Gene name	RPS6KC1 (HGNC Symbol)
Synonyms	humS6PKh1
Description	Ribosomal protein S6 kinase, 52kDa, polypeptide 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q32.3
Chromosome location (bp)	213051233 - 213274773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136643 (version 83.38)
Entrez gene	26750
UniProt	Q96S38 (UniProt - Evidence at protein level)
neXtProt	NX_Q96S38
Antibodypedia	RPS6KC1 antibodies

PROTEIN BROWSER

RPS6KC1-001	RPS6KC1-002	RPS6KC1-201	RPS6KC1-202	RPS6KC1-203	RPS6KC1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS6KC1-001 ENSP00000355927 ENST00000366960	Q96S38 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0035091 [phosphatidylinositol binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	1066 aa 118.7 kDa	No	0
RPS6KC1-002 ENSP00000355926 ENST00000366959	Q96S38 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0035091 [phosphatidylinositol binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	1054 aa 117.3 kDa	No	0
RPS6KC1-201 ENSP00000439282 ENST00000543354	F6RJM5 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	885 aa 97.9 kDa	No	0
RPS6KC1-202 ENSP00000442306 ENST00000543470	F5H7T0 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0043231 [intracellular membrane-bounded organelle] Show all	854 aa 94.5 kDa	No	0
RPS6KC1-203 ENSP00000483873 ENST00000614059	F5H7T0 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0043231 [intracellular membrane-bounded organelle] Show all	854 aa 94.5 kDa	No	0
RPS6KC1-204 ENSP00000484471 ENST00000615329	A0A087X1U5 [Direct mapping] Ribosomal protein S6 kinase delta-1 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	601 aa 66.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.