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Gene name

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Cancer

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Detectable

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Detectable

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ODF2
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    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ODF2

Gene description

Outer dense fiber of sperm tails 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

17
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in spermatids.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA001874
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and prostate cancer (unfavourable).
Liver cancer p<0.001
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001874

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of colorectal, prostate and ovarian cancers showed moderate cytoplasmic positivity with additional nuclear staining. Remaining malignancies were weakly stained or negative.

GENE INFORMATION

Gene name

ODF2 (HGNC Symbol)

Synonyms

CT134, ODF84

Description

Outer dense fiber of sperm tails 2 (HGNC Symbol)

Entrez gene summary

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

128455186 - 128501292

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136811 (version 83.38)

Entrez gene

4957

UniProt

Q5BJF6 (UniProt - Evidence at protein level)

neXtProt

NX_Q5BJF6

Antibodypedia

ODF2 antibodies

PROTEIN BROWSER

«
ODF2-002
ODF2-003
ODF2-004
ODF2-005
ODF2-006
ODF2-007
ODF2-008
ODF2-009
ODF2-011
ODF2-012
ODF2-014
ODF2-015
ODF2-017
ODF2-018
ODF2-019
ODF2-020
ODF2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ODF2-002
ENSP00000394506
ENST00000444119
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
A0A024R8A5 [Target identity:100%; Query identity:100%]
Outer dense fiber of sperm tails 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
805 aa
93.3 kDa
No 0
ODF2-003
ENSP00000415290
ENST00000446274
Q5T4C8 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
156 aa
17.3 kDa
No 0
ODF2-004
ENSP00000396687
ENST00000448249
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
576 aa
67 kDa
No 0
ODF2-005
ENSP00000377161
ENST00000393527
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
A0A024R8A5 [Target identity:100%; Query identity:100%]
Outer dense fiber of sperm tails 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
805 aa
93.3 kDa
No 0
ODF2-006
ENSP00000361877
ENST00000372791
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
A0A024R8A4 [Target identity:100%; Query identity:100%]
Outer dense fiber of sperm tails 2, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
638 aa
73.3 kDa
No 0
ODF2-007
ENSP00000475118
ENST00000470061
S4R462 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
100 aa
10.6 kDa
No 0
ODF2-008
ENSP00000361901
ENST00000372814
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
701 aa
80.9 kDa
No 0
ODF2-009
ENSP00000361893
ENST00000372807
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
824 aa
95.3 kDa
No 0
ODF2-011
ENSP00000403453
ENST00000434106
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0001520 [outer dense fiber]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0007286 [spermatid development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
829 aa
95.4 kDa
No 0
ODF2-012
ENSP00000407852
ENST00000432065
Q5T4C6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
205 aa
23.4 kDa
No 0
ODF2-014
ENSP00000474949
ENST00000497812
S4R411 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
144 aa
16 kDa
No 0
ODF2-015
ENSP00000474651
ENST00000483070
S4R3R9 [Direct mapping]
Outer dense fiber protein 2
Show all
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
241 aa
27.6 kDa
No 0
ODF2-017
ENSP00000473949
ENST00000604420
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
829 aa
95.4 kDa
No 0
ODF2-018
ENSP00000377166
ENST00000393533
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
657 aa
75.7 kDa
No 0
ODF2-019
ENSP00000437579
ENST00000546203
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
638 aa
73.7 kDa
No 0
ODF2-020
ENSP00000395489
ENST00000421776
Q5T4C3 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
386 aa
44.3 kDa
No 0
ODF2-201
ENSP00000342581
ENST00000351030
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
824 aa
95.3 kDa
No 0

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