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ODF2

GENERAL INFORMATION

Gene name

 ODF2

Gene description

 Outer dense fiber of sperm tails 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in spermatids.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA001874
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and prostate cancer (unfavourable).
Liver cancer p<0.001
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001874

GENE INFORMATION

Gene name

 ODF2 (HGNC Symbol)

Synonyms

 CT134, ODF84

Description

 Outer dense fiber of sperm tails 2 (HGNC Symbol)

Entrez gene summary

 The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128455186 - 128501292

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136811 (version 83.38)

Entrez gene

 4957

UniProt

 Q5BJF6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5BJF6

Antibodypedia

 ODF2 antibodies

PROTEIN BROWSER
«
ODF2-002
ODF2-003
ODF2-004
ODF2-005
ODF2-006
ODF2-007
ODF2-008
ODF2-009
ODF2-011
ODF2-012
ODF2-014
ODF2-015
ODF2-017
ODF2-018
ODF2-019
ODF2-020
ODF2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ODF2-002
ENSP00000394506
ENST00000444119
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
A0A024R8A5 [Target identity:100%; Query identity:100%]
Outer dense fiber of sperm tails 2, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
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 805 aa
93.3 kDa 		No 0
ODF2-003
ENSP00000415290
ENST00000446274
Q5T4C8 [Direct mapping]
Outer dense fiber protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 156 aa
17.3 kDa 		No 0
ODF2-004
ENSP00000396687
ENST00000448249
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 576 aa
67 kDa 		No 0
ODF2-005
ENSP00000377161
ENST00000393527
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
A0A024R8A5 [Target identity:100%; Query identity:100%]
Outer dense fiber of sperm tails 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 805 aa
93.3 kDa 		No 0
ODF2-006
ENSP00000361877
ENST00000372791
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
A0A024R8A4 [Target identity:100%; Query identity:100%]
Outer dense fiber of sperm tails 2, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 638 aa
73.3 kDa 		No 0
ODF2-007
ENSP00000475118
ENST00000470061
S4R462 [Direct mapping]
Outer dense fiber protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 100 aa
10.6 kDa 		No 0
ODF2-008
ENSP00000361901
ENST00000372814
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 701 aa
80.9 kDa 		No 0
ODF2-009
ENSP00000361893
ENST00000372807
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 824 aa
95.3 kDa 		No 0
ODF2-011
ENSP00000403453
ENST00000434106
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0001520 [outer dense fiber]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0007286 [spermatid development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 829 aa
95.4 kDa 		No 0
ODF2-012
ENSP00000407852
ENST00000432065
Q5T4C6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 205 aa
23.4 kDa 		No 0
ODF2-014
ENSP00000474949
ENST00000497812
S4R411 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
16 kDa 		No 0
ODF2-015
ENSP00000474651
ENST00000483070
S4R3R9 [Direct mapping]
Outer dense fiber protein 2
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   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 241 aa
27.6 kDa 		No 0
ODF2-017
ENSP00000473949
ENST00000604420
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 829 aa
95.4 kDa 		No 0
ODF2-018
ENSP00000377166
ENST00000393533
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 657 aa
75.7 kDa 		No 0
ODF2-019
ENSP00000437579
ENST00000546203
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 638 aa
73.7 kDa 		No 0
ODF2-020
ENSP00000395489
ENST00000421776
Q5T4C3 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 386 aa
44.3 kDa 		No 0
ODF2-201
ENSP00000342581
ENST00000351030
Q5BJF6 [Direct mapping]
Outer dense fiber protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organismal development]
GO:0017137 [Rab GTPase binding]
GO:0036064 [ciliary basal body]
GO:0072372 [primary cilium]
GO:1902017 [regulation of cilium assembly]
Show all
 824 aa
95.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.