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SMC2

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GENERAL INFORMATION

Gene name

 SMC2

Gene description

 Structural maintenance of chromosomes 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Nucleoli (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA071309
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

 Nucleus (supported)

Additional location

 Nucleoli (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA071309 HaCaT Nucleus Intensity
HPA071309 RH-30 Nucleus Intensity
HPA071309 U-2 OS Nucleus Intensity Intensity
Nucleoli

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA071309 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. SMC2 is mostly expressed during S and/or G2, and during Mitosis.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

Intensity variation

 Nucleus

GENE INFORMATION

Gene name

 SMC2 (HGNC Symbol)

Synonyms

 CAP-E, hCAP-E, SMC2L1

Description

 Structural maintenance of chromosomes 2 (HGNC Symbol)

Entrez gene summary

 Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

Chromosome

 9

Cytoband

 q31.1

Chromosome location (bp)

 104094260 - 104141417

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136824 (version 83.38)

Entrez gene

 10592

UniProt

 O95347 (UniProt - Evidence at protein level)

neXtProt

 NX_O95347

Antibodypedia

 SMC2 antibodies

PROTEIN BROWSER
SMC2-001
SMC2-002
SMC2-004
SMC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMC2-001
ENSP00000363925
ENST00000374793
O95347 [Direct mapping]
Structural maintenance of chromosomes protein 2
A0A024R158 [Target identity:100%; Query identity:100%]
Structural maintenance of chromosomes protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0000796 [condensin complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007076 [mitotic chromosome condensation]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
Show all
 1197 aa
135.7 kDa 		No 0
SMC2-002
ENSP00000363919
ENST00000374787
O95347 [Direct mapping]
Structural maintenance of chromosomes protein 2
A0A024R158 [Target identity:100%; Query identity:100%]
Structural maintenance of chromosomes protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0000796 [condensin complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007076 [mitotic chromosome condensation]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
Show all
 1197 aa
135.7 kDa 		No 0
SMC2-004
ENSP00000414999
ENST00000440179
Q5T821 [Direct mapping]
Structural maintenance of chromosomes protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000796 [condensin complex]
GO:0007076 [mitotic chromosome condensation]
Show all
 145 aa
17.3 kDa 		No 0
SMC2-201
ENSP00000286398
ENST00000286398
O95347 [Direct mapping]
Structural maintenance of chromosomes protein 2
A0A024R158 [Target identity:100%; Query identity:100%]
Structural maintenance of chromosomes protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0000796 [condensin complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007076 [mitotic chromosome condensation]
GO:0010032 [meiotic chromosome condensation]
GO:0045132 [meiotic chromosome segregation]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051383 [kinetochore organization]
GO:0070062 [extracellular exosome]
Show all
 1197 aa
135.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.