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SMC2

GENERAL INFORMATION

Gene name

 SMC2

Gene description

 Structural maintenance of chromosomes 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nucleolar expression in several tissues, most abundant in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA071309
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA071309

GENE INFORMATION

Gene name

 SMC2 (HGNC Symbol)

Synonyms

 CAP-E, hCAP-E, SMC2L1

Description

 Structural maintenance of chromosomes 2 (HGNC Symbol)

Entrez gene summary

 Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

Chromosome

 9

Cytoband

 q31.1

Chromosome location (bp)

 104094260 - 104141417

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136824 (version 83.38)

Entrez gene

 10592

UniProt

 O95347 (UniProt - Evidence at protein level)

neXtProt

 NX_O95347

Antibodypedia

 SMC2 antibodies

PROTEIN BROWSER
SMC2-001
SMC2-002
SMC2-004
SMC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMC2-001
ENSP00000363925
ENST00000374793
O95347 [Direct mapping]
Structural maintenance of chromosomes protein 2
A0A024R158 [Target identity:100%; Query identity:100%]
Structural maintenance of chromosomes protein
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0000796 [condensin complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007076 [mitotic chromosome condensation]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
Show all
 1197 aa
135.7 kDa 		No 0
SMC2-002
ENSP00000363919
ENST00000374787
O95347 [Direct mapping]
Structural maintenance of chromosomes protein 2
A0A024R158 [Target identity:100%; Query identity:100%]
Structural maintenance of chromosomes protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0000796 [condensin complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007076 [mitotic chromosome condensation]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
Show all
 1197 aa
135.7 kDa 		No 0
SMC2-004
ENSP00000414999
ENST00000440179
Q5T821 [Direct mapping]
Structural maintenance of chromosomes protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000796 [condensin complex]
GO:0007076 [mitotic chromosome condensation]
Show all
 145 aa
17.3 kDa 		No 0
SMC2-201
ENSP00000286398
ENST00000286398
O95347 [Direct mapping]
Structural maintenance of chromosomes protein 2
A0A024R158 [Target identity:100%; Query identity:100%]
Structural maintenance of chromosomes protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0000796 [condensin complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007076 [mitotic chromosome condensation]
GO:0010032 [meiotic chromosome condensation]
GO:0045132 [meiotic chromosome segregation]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051383 [kinetochore organization]
GO:0070062 [extracellular exosome]
Show all
 1197 aa
135.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.