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TLR4

GENERAL INFORMATION

Gene name

 TLR4

Gene description

 Toll-like receptor 4

Protein class

 CD markers
Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Karpas-707, TIME)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA049174 , CAB004025
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PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (unfavourable) and endometrial cancer (favourable).
Testis cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049174
CAB004025

GENE INFORMATION

Gene name

 TLR4 (HGNC Symbol)

Synonyms

 ARMD10, CD284, hToll, TLR-4

Description

 Toll-like receptor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 9

Cytoband

 q33.1

Chromosome location (bp)

 117704332 - 117716871

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136869 (version 83.38)

Entrez gene

 7099

UniProt

 O00206 (UniProt - Evidence at protein level)

neXtProt

 NX_O00206

Antibodypedia

 TLR4 antibodies

PROTEIN BROWSER
TLR4-001
TLR4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLR4-001
ENSP00000363089
ENST00000355622
O00206 [Direct mapping]
Toll-like receptor 4
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001530 [lipopolysaccharide binding]
GO:0001875 [lipopolysaccharide receptor activity]
GO:0002218 [activation of innate immune response]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002322 [B cell proliferation involved in immune response]
GO:0002537 [nitric oxide production involved in inflammatory response]
GO:0002730 [regulation of dendritic cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007252 [I-kappaB phosphorylation]
GO:0009617 [response to bacterium]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010572 [positive regulation of platelet activation]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014002 [astrocyte development]
GO:0016021 [integral component of membrane]
GO:0016046 [detection of fungus]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032497 [detection of lipopolysaccharide]
GO:0032609 [interferon-gamma production]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032707 [negative regulation of interleukin-23 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032722 [positive regulation of chemokine production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042088 [T-helper 1 type immune response]
GO:0042116 [macrophage activation]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042742 [defense response to bacterium]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045084 [positive regulation of interleukin-12 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045359 [positive regulation of interferon-beta biosynthetic process]
GO:0045416 [positive regulation of interleukin-8 biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050707 [regulation of cytokine secretion]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:0060729 [intestinal epithelial structure maintenance]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070430 [positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway]
GO:0070434 [positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0071260 [cellular response to mechanical stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
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 839 aa
95.7 kDa 		Yes 1
TLR4-002
ENSP00000377997
ENST00000394487
O00206 [Direct mapping]
Toll-like receptor 4
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001530 [lipopolysaccharide binding]
GO:0001875 [lipopolysaccharide receptor activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007252 [I-kappaB phosphorylation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010572 [positive regulation of platelet activation]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016021 [integral component of membrane]
GO:0016046 [detection of fungus]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032497 [detection of lipopolysaccharide]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032707 [negative regulation of interleukin-23 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032722 [positive regulation of chemokine production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042088 [T-helper 1 type immune response]
GO:0042116 [macrophage activation]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042742 [defense response to bacterium]
GO:0045084 [positive regulation of interleukin-12 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045416 [positive regulation of interleukin-8 biosynthetic process]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050707 [regulation of cytokine secretion]
GO:0050729 [positive regulation of inflammatory response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:0060729 [intestinal epithelial structure maintenance]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 799 aa
91.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.