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PRPF4

GENERAL INFORMATION

Gene name

 PRPF4

Gene description

 Pre-mRNA processing factor 4

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021794 , HPA022248
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021794
HPA022248

GENE INFORMATION

Gene name

 PRPF4 (HGNC Symbol)

Synonyms

 HPRP4, HPRP4P, PRP4, Prp4p, SNRNP60

Description

 Pre-mRNA processing factor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 9

Cytoband

 q32

Chromosome location (bp)

 113275343 - 113292905

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136875 (version 83.38)

Entrez gene

 9128

UniProt

 O43172 (UniProt - Evidence at protein level)

neXtProt

 NX_O43172

Antibodypedia

 PRPF4 antibodies

PROTEIN BROWSER
PRPF4-001
PRPF4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRPF4-001
ENSP00000363315
ENST00000374199
O43172 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp4
Q5T1M7 [Target identity:100%; Query identity:100%]
60 kDa U4/U6 snRNP-specific spliceosomal protein; PRP4 pre-mRNA processing factor 4 homolog (Yeast), isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
GO:0097525 [spliceosomal snRNP complex]
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 521 aa
58.3 kDa 		No 0
PRPF4-002
ENSP00000363313
ENST00000374198
O43172 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp4
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
GO:0097525 [spliceosomal snRNP complex]
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 522 aa
58.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.