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PRPF4

GENERAL INFORMATION

Gene name

 PRPF4

Gene description

 Pre-mRNA processing factor 4

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021794 , HPA022248
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRPF4 (HGNC Symbol)

Synonyms

 HPRP4, HPRP4P, PRP4, Prp4p, SNRNP60

Description

 Pre-mRNA processing factor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 9

Cytoband

 q32

Chromosome location (bp)

 113275343 - 113292905

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136875 (version 83.38)

Entrez gene

 9128

UniProt

 O43172 (UniProt - Evidence at protein level)

neXtProt

 NX_O43172

Antibodypedia

 PRPF4 antibodies

PROTEIN BROWSER
PRPF4-001
PRPF4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRPF4-001
ENSP00000363315
ENST00000374199
O43172 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp4
Q5T1M7 [Target identity:100%; Query identity:100%]
60 kDa U4/U6 snRNP-specific spliceosomal protein; PRP4 pre-mRNA processing factor 4 homolog (Yeast), isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
GO:0097525 [spliceosomal snRNP complex]
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 521 aa
58.3 kDa 		No 0
PRPF4-002
ENSP00000363313
ENST00000374198
O43172 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp4
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
GO:0097525 [spliceosomal snRNP complex]
Show all
 522 aa
58.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.