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BAAT

GENERAL INFORMATION

Gene name

 BAAT

Gene description

 Bile acid CoA:amino acid N-acyltransferase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Group enriched (gallbladder, liver)

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in hepatocytes and gallbladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA021330
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (gallbladder, liver)

GENE INFORMATION

Gene name

 BAAT (HGNC Symbol)

Synonyms

 BAT

Description

 Bile acid CoA:amino acid N-acyltransferase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q31.1

Chromosome location (bp)

 101360417 - 101383519

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136881 (version 83.38)

Entrez gene

 570

UniProt

 Q14032 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14032

Antibodypedia

 BAAT antibodies

PROTEIN BROWSER
BAAT-001
BAAT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAAT-001
ENSP00000378491
ENST00000395051
Q14032 [Direct mapping]
Bile acid-CoA:amino acid N-acyltransferase
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Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002152 [bile acid conjugation]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006544 [glycine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0006699 [bile acid biosynthetic process]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0016410 [N-acyltransferase activity]
GO:0016790 [thiolester hydrolase activity]
GO:0019530 [taurine metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047963 [glycine N-choloyltransferase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0052815 [medium-chain acyl-CoA hydrolase activity]
GO:0052816 [long-chain acyl-CoA hydrolase activity]
GO:0052817 [very long chain acyl-CoA hydrolase activity]
Show all
 418 aa
46.3 kDa 		No 0
BAAT-201
ENSP00000259407
ENST00000259407
Q14032 [Direct mapping]
Bile acid-CoA:amino acid N-acyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0002152 [bile acid conjugation]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006544 [glycine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0006699 [bile acid biosynthetic process]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0016410 [N-acyltransferase activity]
GO:0016790 [thiolester hydrolase activity]
GO:0019530 [taurine metabolic process]
GO:0031100 [organ regeneration]
GO:0044281 [small molecule metabolic process]
GO:0047963 [glycine N-choloyltransferase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0052815 [medium-chain acyl-CoA hydrolase activity]
GO:0052816 [long-chain acyl-CoA hydrolase activity]
GO:0052817 [very long chain acyl-CoA hydrolase activity]
Show all
 418 aa
46.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.