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XPA

GENERAL INFORMATION

Gene name

 XPA

Gene description

 Xeroderma pigmentosum, complementation group A

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in a majority of the tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB000155
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 XPA (HGNC Symbol)

Synonyms

 XP1, XPAC

Description

 Xeroderma pigmentosum, complementation group A (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 9

Cytoband

 q22.33

Chromosome location (bp)

 97674909 - 97697357

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136936 (version 83.38)

Entrez gene

 7507

UniProt

 P23025 (UniProt - Evidence at protein level)

neXtProt

 NX_P23025

Antibodypedia

 XPA antibodies

PROTEIN BROWSER
XPA-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XPA-001
ENSP00000364270
ENST00000375128
P23025 [Direct mapping]
DNA repair protein complementing XP-A cells
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006979 [response to oxidative stress]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009411 [response to UV]
GO:0009636 [response to toxic substance]
GO:0010996 [response to auditory stimulus]
GO:0019904 [protein domain specific binding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0035264 [multicellular organism growth]
GO:0042803 [protein homodimerization activity]
GO:0045171 [intercellular bridge]
GO:0046872 [metal ion binding]
GO:0070911 [global genome nucleotide-excision repair]
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 273 aa
31.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.