Fields »
ABOUT
HELP
BLOG
MYC

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 MYC

Gene description

 V-myc avian myelocytomatosis viral oncogene homolog

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA055893 , HPA066556
SHOW MORE

ASSAYS
RNA expression
Human cells
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055893 PC-3 Nucleoplasm
HPA055893 U-2 OS Nucleoplasm
HPA055893 U-251 MG Nucleoplasm
HPA066556 HEK 293 Nucleoplasm
HPA066556 SK-MEL-30 Nucleoplasm
HPA066556 U-2 OS Nucleoplasm

GFP

Antibody

 HPA055893

Validation

C-terminal tag
BAC cell line: 5379
Validated: Antibody staining overlaps with GFP tagged protein

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA055893 HeLa 5379 C-terminal Nucleoplasm Nucleoplasm
HPA055893 HeLa Normal - Nucleoplasm -

GENE INFORMATION

Gene name

 MYC (HGNC Symbol)

Synonyms

 bHLHe39, c-Myc, MYCC

Description

 V-myc avian myelocytomatosis viral oncogene homolog (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.21

Chromosome location (bp)

 127735434 - 127741434

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136997 (version 83.38)

Entrez gene

 4609

UniProt

 P01106 (UniProt - Evidence at protein level)

neXtProt

 NX_P01106

Antibodypedia

 MYC antibodies

PROTEIN BROWSER
MYC-001
MYC-002
MYC-003
MYC-004
MYC-005
MYC-006
MYC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYC-001
ENSP00000478887
ENST00000621592
A0A087WUS5 [Direct mapping]
Myc proto-oncogene protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 454 aa
50.5 kDa 		No 0
MYC-002
ENSP00000259523
ENST00000259523
A0A0B4J1R1 [Direct mapping]
Myc proto-oncogene protein; V-myc myelocytomatosis viral oncogene homolog (Avian), isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 257 aa
27.8 kDa 		No 0
MYC-003
ENSP00000429441
ENST00000517291
H0YBG3 [Direct mapping]
Myc proto-oncogene protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 184 aa
20.5 kDa 		No 0
MYC-004
ENSP00000430235
ENST00000524013
H0YBT0 [Direct mapping]
Myc proto-oncogene protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 453 aa
50.4 kDa 		No 0
MYC-005
ENSP00000430226
ENST00000520751
E5RGD7 [Direct mapping]
Myc proto-oncogene protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.3 kDa 		No 0
MYC-006
ENSP00000367207
ENST00000377970
P01106 [Direct mapping]
Myc proto-oncogene protein
A0A024R9L7 [Target identity:100%; Query identity:100%]
V-myc myelocytomatosis viral oncogene homolog (Avian), isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006879 [cellular iron ion homeostasis]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0015671 [oxygen transport]
GO:0032204 [regulation of telomere maintenance]
GO:0032403 [protein complex binding]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0034644 [cellular response to UV]
GO:0035690 [cellular response to drug]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044346 [fibroblast apoptotic process]
GO:0045656 [negative regulation of monocyte differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051276 [chromosome organization]
GO:0051782 [negative regulation of cell division]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070491 [repressing transcription factor binding]
GO:0070848 [response to growth factor]
GO:0070888 [E-box binding]
GO:0090096 [positive regulation of metanephric cap mesenchymal cell proliferation]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001022 [positive regulation of response to DNA damage stimulus]
Show all
 439 aa
48.8 kDa 		No 0
MYC-201
ENSP00000479618
ENST00000613283
A0A087WUS5 [Direct mapping]
Myc proto-oncogene protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 454 aa
50.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.