Expression of MYC in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	MYC
Gene descriptionⁱ Gene description according to HGNC.	V-myc avian myelocytomatosis viral oncogene homolog
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Ubiquitous nuclear and nucleolar expression in essentially all cells except in glial- and stroma cells.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 3 antibodies. HPA055893 , CAB000084 , CAB010307
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (unfavourable), urothelial cancer (unfavourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA055893	CAB000084	CAB010307

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	MYC (HGNC Symbol)
Synonyms	bHLHe39, c-Myc, MYCC
Description	V-myc avian myelocytomatosis viral oncogene homolog (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.21
Chromosome location (bp)	127735434 - 127741434
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136997 (version 83.38)
Entrez gene	4609
UniProt	P01106 (UniProt - Evidence at protein level)
neXtProt	NX_P01106
Antibodypedia	MYC antibodies

PROTEIN BROWSERⁱ

MYC-001	MYC-002	MYC-003	MYC-004	MYC-005	MYC-006	MYC-201

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYC-001 ENSP00000478887 ENST00000621592	A0A087WUS5 [Direct mapping] Myc proto-oncogene protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	454 aa 50.5 kDa	No	0
MYC-002 ENSP00000259523 ENST00000259523	A0A0B4J1R1 [Direct mapping] Myc proto-oncogene protein; V-myc myelocytomatosis viral oncogene homolog (Avian), isoform CRA_b Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	257 aa 27.8 kDa	No	0
MYC-003 ENSP00000429441 ENST00000517291	H0YBG3 [Direct mapping] Myc proto-oncogene protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	184 aa 20.5 kDa	No	0
MYC-004 ENSP00000430235 ENST00000524013	H0YBT0 [Direct mapping] Myc proto-oncogene protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	453 aa 50.4 kDa	No	0
MYC-005 ENSP00000430226 ENST00000520751	E5RGD7 [Direct mapping] Myc proto-oncogene protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.3 kDa	No	0
MYC-006 ENSP00000367207 ENST00000377970	P01106 [Direct mapping] Myc proto-oncogene protein A0A024R9L7 [Target identity:100%; Query identity:100%] V-myc myelocytomatosis viral oncogene homolog (Avian), isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0006112 [energy reserve metabolic process] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006879 [cellular iron ion homeostasis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0010468 [regulation of gene expression] GO:0015671 [oxygen transport] GO:0032204 [regulation of telomere maintenance] GO:0032403 [protein complex binding] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0034644 [cellular response to UV] GO:0035690 [cellular response to drug] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044346 [fibroblast apoptotic process] GO:0045656 [negative regulation of monocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048147 [negative regulation of fibroblast proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051276 [chromosome organization] GO:0051782 [negative regulation of cell division] GO:0060070 [canonical Wnt signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070848 [response to growth factor] GO:0070888 [E-box binding] GO:0090096 [positive regulation of metanephric cap mesenchymal cell proliferation] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2001022 [positive regulation of response to DNA damage stimulus] Show all	439 aa 48.8 kDa	No	0
MYC-201 ENSP00000479618 ENST00000613283	A0A087WUS5 [Direct mapping] Myc proto-oncogene protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	454 aa 50.5 kDa	No	0