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Several cases of melanomas and colorectal cancers along with few liver, testis, urothelial, prostatic, ovarian, cervical, renal and head and neck cancers showed moderate nucleolar positivity. Remaining cancer tissues were in general weakly stained or negative.
Moderate nuclear and sometimes cytoplasmic positivity was observed in most cancers. Skin, urothelial, stomach and pancreatic cancers were mainly weak or negative.
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
A0A087WUS5 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]
H0YBG3 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]
H0YBT0 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity]
E5RGD7 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0006112 [energy reserve metabolic process] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006879 [cellular iron ion homeostasis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0010468 [regulation of gene expression] GO:0015671 [oxygen transport] GO:0032204 [regulation of telomere maintenance] GO:0032403 [protein complex binding] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0034644 [cellular response to UV] GO:0035690 [cellular response to drug] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044346 [fibroblast apoptotic process] GO:0045656 [negative regulation of monocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048147 [negative regulation of fibroblast proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051276 [chromosome organization] GO:0051782 [negative regulation of cell division] GO:0060070 [canonical Wnt signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070848 [response to growth factor] GO:0070888 [E-box binding] GO:0090096 [positive regulation of metanephric cap mesenchymal cell proliferation] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2001022 [positive regulation of response to DNA damage stimulus]
A0A087WUS5 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity]