Expression of TMEM63B in cancer - Summary

GENERAL INFORMATION
Gene name	TMEM63B
Gene description	Transmembrane protein 63B
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct membranous expression in several different cell types, including expression in renal tubules and in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA029249 , HPA029251
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029249	HPA029251

GENE INFORMATION
Gene name	TMEM63B (HGNC Symbol)
Synonyms	C6orf110, dJ421H19.2, DKFZp434P0531
Description	Transmembrane protein 63B (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	44126914 - 44155519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137216 (version 83.38)
Entrez gene	55362
UniProt	Q5T3F8 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T3F8
Antibodypedia	TMEM63B antibodies

PROTEIN BROWSER

TMEM63B-004	TMEM63B-005	TMEM63B-008	TMEM63B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM63B-004 ENSP00000360960 ENST00000371893	H3BLW6 [Direct mapping] CSC1-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	761 aa 86.7 kDa	No	9
TMEM63B-005 ENSP00000259746 ENST00000259746	Q5T3F8 [Direct mapping] CSC1-like protein 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	832 aa 95 kDa	Yes	>9
TMEM63B-008 ENSP00000437163 ENST00000532634	E9PNG1 [Direct mapping] CSC1-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	226 aa 25.6 kDa	Yes	3
TMEM63B-201 ENSP00000327154 ENST00000323267	Q5T3F8 [Direct mapping] CSC1-like protein 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	832 aa 95 kDa	Yes	>9