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Several cases of malignant melanoma, prostate cancer and seminomas showed moderate nuclear and cytoplasmic immunoreactivity. Other cancers were weakly stained or negative.
A few cases of lymphoma displayed moderate to strong nuclear and cytoplasmic immunoreactivity. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
IRF4 (HGNC Symbol)
Synonyms
LSIRF, MUM1
Description
Interferon regulatory factor 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000788 [nuclear nucleosome] GO:0000975 [regulatory region DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006479 [protein methylation] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0016279 [protein-lysine N-methyltransferase activity] GO:0018022 [peptidyl-lysine methylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0034122 [negative regulation of toll-like receptor signaling pathway] GO:0042110 [T cell activation] GO:0042832 [defense response to protozoan] GO:0043011 [myeloid dendritic cell differentiation] GO:0043388 [positive regulation of DNA binding] GO:0043565 [sequence-specific DNA binding] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0045082 [positive regulation of interleukin-10 biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045368 [positive regulation of interleukin-13 biosynthetic process] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045622 [regulation of T-helper cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0072540 [T-helper 17 cell lineage commitment]