Fields »
ABOUT
HELP
BLOG
TUBB2A

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 TUBB2A

Gene description

 Tubulin, beta 2A class IIa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the microtubules.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB015339 , HPA043640
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the microtubules.

Main location

 Microtubules (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB015339 A-431 Microtubules Intensity
CAB015339 U-2 OS Microtubules Intensity
CAB015339 U-251 MG Microtubules Intensity
HPA043640 A-431 Microtubules
HPA043640 U-2 OS Microtubules
HPA043640 U-251 MG Microtubules

GENE INFORMATION

Gene name

 TUBB2A (HGNC Symbol)

Synonyms

 dJ40E16.7, TUBB, TUBB2

Description

 Tubulin, beta 2A class IIa (HGNC Symbol)

Entrez gene summary

 Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 3153669 - 3157526

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137267 (version 83.38)

Entrez gene

 7280

UniProt

 Q13885 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13885

Antibodypedia

 TUBB2A antibodies

PROTEIN BROWSER
TUBB2A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB2A-001
ENSP00000369703
ENST00000333628
Q13885 [Direct mapping]
Tubulin beta-2A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 445 aa
49.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.