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TUBB2A

GENERAL INFORMATION

Gene name

 TUBB2A

Gene description

 Tubulin, beta 2A class IIa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in CNS and peripheral nerves.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Supported based on 3 antibodies.
HPA043640 , HPA046280 , CAB015339
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and renal cancer (favourable).
Urothelial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA043640
HPA046280
CAB015339

GENE INFORMATION

Gene name

 TUBB2A (HGNC Symbol)

Synonyms

 dJ40E16.7, TUBB, TUBB2

Description

 Tubulin, beta 2A class IIa (HGNC Symbol)

Entrez gene summary

 Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 3153669 - 3157526

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137267 (version 83.38)

Entrez gene

 7280

UniProt

 Q13885 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13885

Antibodypedia

 TUBB2A antibodies

PROTEIN BROWSER
TUBB2A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB2A-001
ENSP00000369703
ENST00000333628
Q13885 [Direct mapping]
Tubulin beta-2A chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
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 445 aa
49.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.