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GCM1

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GENERAL INFORMATION

Gene name

 GCM1

Gene description

 Glial cells missing homolog 1 (Drosophila)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enriched (BEWO)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA011343
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA011343 CACO-2 Vesicles
HPA011343 U-2 OS Vesicles
HPA011343 U-251 MG No staining    

GENE INFORMATION

Gene name

 GCM1 (HGNC Symbol)

Synonyms

 GCMA, hGCMa

Description

 Glial cells missing homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p12.1

Chromosome location (bp)

 53126964 - 53148829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137270 (version 83.38)

Entrez gene

 8521

UniProt

 Q9NP62 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NP62

Antibodypedia

 GCM1 antibodies

PROTEIN BROWSER
GCM1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GCM1-001
ENSP00000259803
ENST00000259803
Q9NP62 [Direct mapping]
Chorion-specific transcription factor GCMa
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Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0042826 [histone deacetylase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060018 [astrocyte fate commitment]
GO:0060143 [positive regulation of syncytium formation by plasma membrane fusion]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060706 [cell differentiation involved in embryonic placenta development]
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 436 aa
49.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.