Expression of TUBB2B in cancer - Summary

GENERAL INFORMATION
Gene name	TUBB2B
Gene description	Tubulin, beta 2B class IIb
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (AF22, CACO-2, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, most abundant in ciliated cells and peripheral nerves.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. External characterization data supports antibody staining.
Reliability score	Supported based on 2 antibodies. HPA043640 , HPA046280
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043640	HPA046280

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	A few gliomas, carcinoids, cholangiocarcinomas, thyroid, testicular, prostate, ovarian and pancreatic cancers showed weak to moderate staining. Other cancer cells were negative.

GENE INFORMATION
Gene name	TUBB2B (HGNC Symbol)
Synonyms	bA506K6.1, DKFZp566F223, MGC8685
Description	Tubulin, beta 2B class IIb (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	3224261 - 3231730
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137285 (version 83.38)
Entrez gene	347733
UniProt	Q9BVA1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVA1
Antibodypedia	TUBB2B antibodies

PROTEIN BROWSER

TUBB2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUBB2B-001 ENSP00000259818 ENST00000259818	Q9BVA1 [Direct mapping] Tubulin beta-2B chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007017 [microtubule-based process] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] Show all	445 aa 50 kDa	No	0