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TUBB2B

GENERAL INFORMATION

Gene name

 TUBB2B

Gene description

 Tubulin, beta 2B class IIb

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues, most abundant in ciliated cells and peripheral nerves.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA043640 , HPA046280
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200250300350TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin050100150200RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0100200300400Tags Per Million

GENE INFORMATION

Gene name

 TUBB2B (HGNC Symbol)

Synonyms

 bA506K6.1, DKFZp566F223, MGC8685

Description

 Tubulin, beta 2B class IIb (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 3224261 - 3231730

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137285 (version 83.38)

Entrez gene

 347733

UniProt

 Q9BVA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BVA1

Antibodypedia

 TUBB2B antibodies

PROTEIN BROWSER
TUBB2B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB2B-001
ENSP00000259818
ENST00000259818
Q9BVA1 [Direct mapping]
Tubulin beta-2B chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
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 445 aa
50 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.