Cell atlas - MDC1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MDC1

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MDC1
Gene description	Mediator of DNA-damage checkpoint 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HEK 293, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (supported)
Additional location	In addition localized to the Nucleoplasm (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA006915
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.

Main location

Nuclear bodies (supported)

Additional location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006915	A-431	Nucleoplasm	Intensity
	HPA006915	A-431	Nuclear bodies	Intensity
	HPA006915	U-2 OS	Nucleoplasm
	HPA006915	U-2 OS	Nuclear bodies
	HPA006915	U-251 MG	Nucleoplasm
			Nuclear bodies
			Focal adhesion sites

GENE INFORMATION
Gene name	MDC1 (HGNC Symbol)
Synonyms	Em:AB023051.5, KIAA0170, NFBD1
Description	Mediator of DNA-damage checkpoint 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	30699807 - 30717889
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137337 (version 83.38)
Entrez gene	9656
UniProt	Q14676 (UniProt - Evidence at protein level)
neXtProt	NX_Q14676
Antibodypedia	MDC1 antibodies

PROTEIN BROWSER

MDC1-001	MDC1-002	MDC1-003	MDC1-004	MDC1-006	MDC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MDC1-001 ENSP00000365588 ENST00000376406	Q14676 [Direct mapping] Mediator of DNA damage checkpoint protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005925 [focal adhesion] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0008022 [protein C-terminus binding] GO:0016925 [protein sumoylation] GO:0031573 [intra-S DNA damage checkpoint] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070975 [FHA domain binding] Show all	2089 aa 226.7 kDa	No	0
MDC1-002 ENSP00000396989 ENST00000425072	A2AB07 [Direct mapping] Mediator of DNA damage checkpoint protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	127 aa 14.2 kDa	No	0
MDC1-003 ENSP00000400979 ENST00000416571	A2AB05 [Direct mapping] Mediator of DNA damage checkpoint protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	162 aa 18.2 kDa	No	0
MDC1-004 ENSP00000411310 ENST00000422266	A2AB06 [Direct mapping] Mediator of DNA damage checkpoint protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	113 aa 12.5 kDa	No	0
MDC1-006 ENSP00000408962 ENST00000417033	H0Y6Z8 [Direct mapping] Mediator of DNA damage checkpoint protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		306 aa 32.8 kDa	No	0
MDC1-201 ENSP00000483601 ENST00000613547	A0A087X0R2 [Direct mapping] Mediator of DNA damage checkpoint protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	142 aa 15.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.