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A majority of malignant cells showed strong nuclear immunoreactivity. Additional membranous staining was found in some liver and colorectal cancers.
GENE INFORMATION
Gene name
MDC1 (HGNC Symbol)
Synonyms
Em:AB023051.5, KIAA0170, NFBD1
Description
Mediator of DNA-damage checkpoint 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Q14676 [Direct mapping] Mediator of DNA damage checkpoint protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)