Expression of MTCH1 in cancer - Summary - The Human Protein Atlas

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MTCH1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MTCH1
Gene description	Mitochondrial carrier 1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA015971
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015971

GENE INFORMATION
Gene name	MTCH1 (HGNC Symbol)
Synonyms	CGI-64, PSAP, SLC25A49
Description	Mitochondrial carrier 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	36968141 - 36986298
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137409 (version 83.38)
Entrez gene	23787
UniProt	Q9NZJ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZJ7
Antibodypedia	MTCH1 antibodies

PROTEIN BROWSER

MTCH1-001	MTCH1-003	MTCH1-005	MTCH1-008	MTCH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTCH1-001 ENSP00000362718 ENST00000373616	Q9NZJ7 [Direct mapping] Mitochondrial carrier homolog 1 A0A024RD08 [Target identity:100%; Query identity:100%] Mitochondrial carrier homolog 1 (C. elegans), isoform CRA_d Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009966 [regulation of signal transduction] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0045161 [neuronal ion channel clustering] Show all	372 aa 39.9 kDa	No	2
MTCH1-003 ENSP00000399187 ENST00000418541	H7C196 [Direct mapping] Mitochondrial carrier homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	201 aa 21.3 kDa	No	2
MTCH1-005 ENSP00000419739 ENST00000460219	H0Y8C3 [Direct mapping] Mitochondrial carrier homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	394 aa 43.1 kDa	No	3
MTCH1-008 ENSP00000362730 ENST00000373627	Q9NZJ7 [Direct mapping] Mitochondrial carrier homolog 1 A0A024RCX4 [Target identity:100%; Query identity:100%] Mitochondrial carrier homolog 1 (C. elegans), isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009966 [regulation of signal transduction] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0045161 [neuronal ion channel clustering] Show all	389 aa 41.5 kDa	No	2
MTCH1-201 ENSP00000437660 ENST00000538808	F6WFU6 [Direct mapping] Mitochondrial carrier homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	363 aa 40 kDa	No	3

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The Human Protein Atlas

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