Tissue expression of MTCH1 - Summary - The Human Protein Atlas

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MTCH1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MTCH1
Gene description	Mitochondrial carrier 1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General granular cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA015971
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MTCH1 (HGNC Symbol)
Synonyms	CGI-64, PSAP, SLC25A49
Description	Mitochondrial carrier 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	36968141 - 36986298
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137409 (version 83.38)
Entrez gene	23787
UniProt	Q9NZJ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZJ7
Antibodypedia	MTCH1 antibodies

PROTEIN BROWSER

MTCH1-001	MTCH1-003	MTCH1-005	MTCH1-008	MTCH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTCH1-001 ENSP00000362718 ENST00000373616	Q9NZJ7 [Direct mapping] Mitochondrial carrier homolog 1 A0A024RD08 [Target identity:100%; Query identity:100%] Mitochondrial carrier homolog 1 (C. elegans), isoform CRA_d Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009966 [regulation of signal transduction] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0045161 [neuronal ion channel clustering] Show all	372 aa 39.9 kDa	No	2
MTCH1-003 ENSP00000399187 ENST00000418541	H7C196 [Direct mapping] Mitochondrial carrier homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	201 aa 21.3 kDa	No	2
MTCH1-005 ENSP00000419739 ENST00000460219	H0Y8C3 [Direct mapping] Mitochondrial carrier homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	394 aa 43.1 kDa	No	3
MTCH1-008 ENSP00000362730 ENST00000373627	Q9NZJ7 [Direct mapping] Mitochondrial carrier homolog 1 A0A024RCX4 [Target identity:100%; Query identity:100%] Mitochondrial carrier homolog 1 (C. elegans), isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009966 [regulation of signal transduction] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0045161 [neuronal ion channel clustering] Show all	389 aa 41.5 kDa	No	2
MTCH1-201 ENSP00000437660 ENST00000538808	F6WFU6 [Direct mapping] Mitochondrial carrier homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	363 aa 40 kDa	No	3

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.