Fields »
ABOUT
HELP
BLOG
CASP1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CASP1

Gene description

 Caspase 1, apoptosis-related cysteine peptidase

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (U-937, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB002685
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

 Cytosol (supported)

Additional location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB002685 A-431 Cytosol
CAB002685 U-2 OS Nucleoplasm
Cytosol
CAB002685 U-251 MG Cytosol

GENE INFORMATION

Gene name

 CASP1 (HGNC Symbol)

Synonyms

 ICE, IL1BC

Description

 Caspase 1, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 105025443 - 105035250

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137752 (version 83.38)

Entrez gene

 834

UniProt

 P29466 (UniProt - Evidence at protein level)

neXtProt

 NX_P29466

Antibodypedia

 CASP1 antibodies

PROTEIN BROWSER
«
CASP1-001
CASP1-002
CASP1-004
CASP1-005
CASP1-007
CASP1-008
CASP1-009
CASP1-010
CASP1-014
CASP1-201
CASP1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASP1-001
ENSP00000410076
ENST00000436863
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 404 aa
45.2 kDa 		No 0
CASP1-002
ENSP00000433138
ENST00000533400
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0009617 [response to bacterium]
GO:0010506 [regulation of autophagy]
GO:0016485 [protein processing]
GO:0032496 [response to lipopolysaccharide]
GO:0032611 [interleukin-1 beta production]
GO:0033198 [response to ATP]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050717 [positive regulation of interleukin-1 alpha secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051882 [mitochondrial depolarization]
GO:0060081 [membrane hyperpolarization]
GO:0070269 [pyroptosis]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
GO:0097300 [programmed necrotic cell death]
GO:1901998 [toxin transport]
Show all
 404 aa
45.2 kDa 		No 0
CASP1-004
ENSP00000434779
ENST00000525825
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 383 aa
42.9 kDa 		No 0
CASP1-005
ENSP00000434259
ENST00000528974
B4DVD8 [Direct mapping]
Caspase-1; cDNA FLJ59442, highly similar to Caspase-1 (EC 3.4.22.36)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0042981 [regulation of apoptotic process]
GO:0050727 [regulation of inflammatory response]
GO:0072557 [IPAF inflammasome complex]
Show all
 301 aa
33 kDa 		No 0
CASP1-007
ENSP00000432340
ENST00000527979
G3V169 [Direct mapping]
Caspase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0042981 [regulation of apoptotic process]
GO:0050727 [regulation of inflammatory response]
GO:0072557 [IPAF inflammasome complex]
Show all
 367 aa
40.9 kDa 		No 0
CASP1-008
ENSP00000436875
ENST00000534497
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 263 aa
29.8 kDa 		No 0
CASP1-009
ENSP00000434250
ENST00000526568
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 311 aa
35 kDa 		No 0
CASP1-010
ENSP00000434303
ENST00000531166
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 88 aa
10.4 kDa 		No 0
CASP1-014
ENSP00000435536
ENST00000532439
H0YEC7 [Direct mapping]
Caspase-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0050727 [regulation of inflammatory response]
GO:0072557 [IPAF inflammasome complex]
Show all
 236 aa
26.7 kDa 		No 0
CASP1-201
ENSP00000344132
ENST00000353247
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 88 aa
10.4 kDa 		No 0
CASP1-202
ENSP00000403260
ENST00000446369
P29466 [Direct mapping]
Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0072557 [IPAF inflammasome complex]
GO:0072558 [NLRP1 inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 263 aa
29.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.