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MAP2K5

GENERAL INFORMATION

Gene name

 MAP2K5

Gene description

 Mitogen-activated protein kinase kinase 5

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA027347 , HPA027755 , CAB022094
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027347
HPA027755
CAB022094

GENE INFORMATION

Gene name

 MAP2K5 (HGNC Symbol)

Synonyms

 HsT17454, MAPKK5, MEK5, PRKMK5

Description

 Mitogen-activated protein kinase kinase 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 67542709 - 67807123

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137764 (version 83.38)

Entrez gene

 5607

UniProt

 Q13163 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13163

Antibodypedia

 MAP2K5 antibodies

PROTEIN BROWSER
MAP2K5-001
MAP2K5-002
MAP2K5-003
MAP2K5-005
MAP2K5-006
MAP2K5-009
MAP2K5-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP2K5-001
ENSP00000178640
ENST00000178640
Q13163 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 5
A0A024R5Y2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase 5, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030307 [positive regulation of cell growth]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045415 [negative regulation of interleukin-8 biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070375 [ERK5 cascade]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:2000342 [negative regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
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 448 aa
50.1 kDa 		No 0
MAP2K5-002
ENSP00000342101
ENST00000340972
A6NK28 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
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 258 aa
29.2 kDa 		No 0
MAP2K5-003
ENSP00000390196
ENST00000439036
H7BZL1 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
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 128 aa
14.1 kDa 		No 0
MAP2K5-005
ENSP00000346493
ENST00000354498
Q13163 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 5
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045415 [negative regulation of interleukin-8 biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:2000342 [negative regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 412 aa
46.1 kDa 		No 0
MAP2K5-006
ENSP00000480580
ENST00000559262
A0A087WWX7 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 182 aa
20.1 kDa 		No 0
MAP2K5-009
ENSP00000483771
ENST00000557869
A0A087X0Z8 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005622 [intracellular]
Show all
 49 aa
5.6 kDa 		No 0
MAP2K5-013
ENSP00000378859
ENST00000395476
Q13163 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 5
A0A024R5X5 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase 5, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045415 [negative regulation of interleukin-8 biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:2000342 [negative regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 438 aa
49 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.