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Malignant cells showed moderate to strong membranous and occasional cytoplasmic staining. Several cases of malignant carcinoids, malignant gliomas, prostate, urothelial and renal cancers were negative.
GENE INFORMATION
Gene name
THBS1 (HGNC Symbol)
Synonyms
THBS, THBS-1, TSP, TSP-1, TSP1
Description
Thrombospondin 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]