Fields »
ABOUT
HELP
BLOG
NUSAP1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 NUSAP1

Gene description

 Nucleolar and spindle associated protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol & nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Nucleoli fibrillar center (supported), Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by correlation analysis and custom assay

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA042904
SHOW MORE

ASSAYS
RNA expression
Human cells
Custom data
Cell cycle

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol & nucleoli (fibrillar center).

Main location

 Nucleus (supported)

Additional location

 Nucleoli fibrillar center (supported), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA042904 A-431 Nucleoplasm
Cytosol
HPA042904 U-2 OS Nucleus Intensity Intensity
Nucleoli fibrillar center Intensity Intensity
HPA042904 U-251 MG Nucleus Intensity
Nucleoli fibrillar center
Cytosol

CUSTOM DATA

 

 

 
Toggle channels

Thumbnail

Antibody

Cell line

Assay

Description
HPA042904 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. NUSAP1 is mostly expressed during S and/or G2.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to correlation analysis and custom assay

Intensity variation

 Nucleoli fibrillar center, Nucleus
HPA042904

GENE INFORMATION

Gene name

 NUSAP1 (HGNC Symbol)

Synonyms

 ANKT, BM037, FLJ13421, LNP, NuSAP1, PRO0310p1, Q0310, SAPL

Description

 Nucleolar and spindle associated protein 1 (HGNC Symbol)

Entrez gene summary

 NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41332694 - 41381050

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137804 (version 83.38)

Entrez gene

 51203

UniProt

 Q9BXS6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXS6

Antibodypedia

 NUSAP1 antibodies

PROTEIN BROWSER
NUSAP1-001
NUSAP1-002
NUSAP1-005
NUSAP1-006
NUSAP1-007
NUSAP1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUSAP1-001
ENSP00000400746
ENST00000414849
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 440 aa
49.3 kDa 		No 0
NUSAP1-002
ENSP00000260359
ENST00000260359
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 426 aa
47.7 kDa 		No 0
NUSAP1-005
ENSP00000401014
ENST00000450592
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 378 aa
42.4 kDa 		No 0
NUSAP1-006
ENSP00000453403
ENST00000559596
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 441 aa
49.5 kDa 		No 0
NUSAP1-007
ENSP00000453657
ENST00000560177
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 440 aa
49.3 kDa 		No 0
NUSAP1-008
ENSP00000454097
ENST00000560747
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 439 aa
49.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.