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NUSAP1

GENERAL INFORMATION

Gene name

 NUSAP1

Gene description

 Nucleolar and spindle associated protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues, most abundant in the nuclear subcellular location of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA042904
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042904

GENE INFORMATION

Gene name

 NUSAP1 (HGNC Symbol)

Synonyms

 ANKT, BM037, FLJ13421, LNP, NuSAP1, PRO0310p1, Q0310, SAPL

Description

 Nucleolar and spindle associated protein 1 (HGNC Symbol)

Entrez gene summary

 NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41332694 - 41381050

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137804 (version 83.38)

Entrez gene

 51203

UniProt

 Q9BXS6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXS6

Antibodypedia

 NUSAP1 antibodies

PROTEIN BROWSER
NUSAP1-001
NUSAP1-002
NUSAP1-005
NUSAP1-006
NUSAP1-007
NUSAP1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUSAP1-001
ENSP00000400746
ENST00000414849
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 440 aa
49.3 kDa 		No 0
NUSAP1-002
ENSP00000260359
ENST00000260359
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 426 aa
47.7 kDa 		No 0
NUSAP1-005
ENSP00000401014
ENST00000450592
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 378 aa
42.4 kDa 		No 0
NUSAP1-006
ENSP00000453403
ENST00000559596
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 441 aa
49.5 kDa 		No 0
NUSAP1-007
ENSP00000453657
ENST00000560177
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 440 aa
49.3 kDa 		No 0
NUSAP1-008
ENSP00000454097
ENST00000560747
Q9BXS6 [Direct mapping]
Nucleolar and spindle-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0007076 [mitotic chromosome condensation]
GO:0008017 [microtubule binding]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044822 [poly(A) RNA binding]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0072686 [mitotic spindle]
Show all
 439 aa
49.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.