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KIF23

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GENERAL INFORMATION

Gene name

 KIF23

Gene description

 Kinesin family member 23

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by correlation analysis and custom assay

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA045208 , HPA068831
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ASSAYS
RNA expression
Human cells
Custom data
Cell cycle

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045208 A549 Nucleoplasm
HPA045208 U-2 OS Nucleoplasm Intensity Intensity
HPA045208 U-251 MG Nucleoplasm
HPA068831 HaCaT Nucleoplasm Intensity
HPA068831 U-2 OS Nucleoplasm Intensity Intensity

CUSTOM DATA

 

 

 
Toggle channels

Thumbnail

Antibody

Cell line

Assay

Description
HPA068831 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. KIF23 is mostly expressed during S and/or G2.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to correlation analysis and custom assay

Intensity variation

 Nucleoplasm
HPA045208

GENE INFORMATION

Gene name

 KIF23 (HGNC Symbol)

Synonyms

 KNSL5, MKLP-1, MKLP1

Description

 Kinesin family member 23 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 69414246 - 69448427

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137807 (version 83.38)

Entrez gene

 9493

UniProt

 Q02241 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02241

Antibodypedia

 KIF23 antibodies

PROTEIN BROWSER
KIF23-001
KIF23-003
KIF23-006
KIF23-007
KIF23-012
KIF23-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF23-001
ENSP00000453386
ENST00000559279
Q02241 [Direct mapping]
Kinesin-like protein KIF23
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
Show all
 856 aa
98.1 kDa 		No 0
KIF23-003
ENSP00000304978
ENST00000352331
Q02241 [Direct mapping]
Kinesin-like protein KIF23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
Show all
 856 aa
98.1 kDa 		No 0
KIF23-006
ENSP00000378790
ENST00000395392
H7BYN4 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 952 aa
109.1 kDa 		No 0
KIF23-007
ENSP00000453102
ENST00000558585
Q02241 [Direct mapping]
Kinesin-like protein KIF23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
Show all
 673 aa
77.7 kDa 		No 0
KIF23-012
ENSP00000452901
ENST00000559283
H0YKQ5 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 267 aa
30.7 kDa 		No 0
KIF23-201
ENSP00000260363
ENST00000260363
Q02241 [Direct mapping]
Kinesin-like protein KIF23
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0045171 [intercellular bridge]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
Show all
 960 aa
110.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.