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KIF23

GENERAL INFORMATION

Gene name

 KIF23

Gene description

 Kinesin family member 23

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB010414
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010414

GENE INFORMATION

Gene name

 KIF23 (HGNC Symbol)

Synonyms

 KNSL5, MKLP-1, MKLP1

Description

 Kinesin family member 23 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 69414246 - 69448427

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137807 (version 83.38)

Entrez gene

 9493

UniProt

 Q02241 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02241

Antibodypedia

 KIF23 antibodies

PROTEIN BROWSER
KIF23-001
KIF23-003
KIF23-006
KIF23-007
KIF23-012
KIF23-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF23-001
ENSP00000453386
ENST00000559279
Q02241 [Direct mapping]
Kinesin-like protein KIF23
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
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 856 aa
98.1 kDa 		No 0
KIF23-003
ENSP00000304978
ENST00000352331
Q02241 [Direct mapping]
Kinesin-like protein KIF23
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
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 856 aa
98.1 kDa 		No 0
KIF23-006
ENSP00000378790
ENST00000395392
H7BYN4 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 952 aa
109.1 kDa 		No 0
KIF23-007
ENSP00000453102
ENST00000558585
Q02241 [Direct mapping]
Kinesin-like protein KIF23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
Show all
 673 aa
77.7 kDa 		No 0
KIF23-012
ENSP00000452901
ENST00000559283
H0YKQ5 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 267 aa
30.7 kDa 		No 0
KIF23-201
ENSP00000260363
ENST00000260363
Q02241 [Direct mapping]
Kinesin-like protein KIF23
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000278 [mitotic cell cycle]
GO:0000281 [mitotic cytokinesis]
GO:0000910 [cytokinesis]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007018 [microtubule-based movement]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0045171 [intercellular bridge]
GO:0051256 [mitotic spindle midzone assembly]
GO:0072686 [mitotic spindle]
GO:0097149 [centralspindlin complex]
Show all
 960 aa
110.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.