Expression of BRDT in cancer - Summary - The Human Protein Atlas

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BRDT

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BRDT
Gene description	Bromodomain, testis-specific
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (lung cancer, testis cancer)
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in spermatocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. CAB012237
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (lung cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB012237

GENE INFORMATION
Gene name	BRDT (HGNC Symbol)
Synonyms	BRD6, CT9
Description	Bromodomain, testis-specific (HGNC Symbol)
Entrez gene summary	BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	1
Cytoband	p22.1
Chromosome location (bp)	91949371 - 92014426
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137948 (version 83.38)
Entrez gene	676
UniProt	Q58F21 (UniProt - Evidence at protein level)
neXtProt	NX_Q58F21
Antibodypedia	BRDT antibodies

PROTEIN BROWSER

BRDT-001	BRDT-002	BRDT-003	BRDT-004	BRDT-005	BRDT-006	BRDT-007	BRDT-008	BRDT-012	BRDT-013	BRDT-016	BRDT-017	BRDT-019	BRDT-020	BRDT-201	BRDT-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRDT-001 ENSP00000354568 ENST00000362005	Q58F21 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0001207 [histone displacement] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006397 [mRNA processing] GO:0007140 [male meiosis] GO:0007141 [male meiosis I] GO:0007283 [spermatogenesis] GO:0008380 [RNA splicing] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0043484 [regulation of RNA splicing] GO:0051039 [positive regulation of transcription during meiosis] GO:0070577 [lysine-acetylated histone binding] Show all	947 aa 108 kDa	No	0
BRDT-002 ENSP00000359416 ENST00000370389	Q58F21 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0001207 [histone displacement] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006397 [mRNA processing] GO:0007140 [male meiosis] GO:0007141 [male meiosis I] GO:0007283 [spermatogenesis] GO:0008380 [RNA splicing] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0043484 [regulation of RNA splicing] GO:0051039 [positive regulation of transcription during meiosis] GO:0070577 [lysine-acetylated histone binding] Show all	874 aa 99.4 kDa	No	0
BRDT-003 ENSP00000416714 ENST00000440509	C9JDL5 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	200 aa 22.8 kDa	No	0
BRDT-004 ENSP00000396351 ENST00000423434	C9JD82 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	176 aa 20.4 kDa	No	0
BRDT-005 ENSP00000404969 ENST00000426141	C9JJU3 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	462 aa 52.8 kDa	No	0
BRDT-006 ENSP00000384051 ENST00000402388	Q58F21 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0001207 [histone displacement] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006397 [mRNA processing] GO:0007140 [male meiosis] GO:0007141 [male meiosis I] GO:0007283 [spermatogenesis] GO:0008380 [RNA splicing] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0043484 [regulation of RNA splicing] GO:0051039 [positive regulation of transcription during meiosis] GO:0070577 [lysine-acetylated histone binding] Show all	947 aa 108 kDa	No	0
BRDT-007 ENSP00000408625 ENST00000449584	C9JMP1 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all		52 aa 6.1 kDa	No	0
BRDT-008 ENSP00000400199 ENST00000355011	C9J0Z0 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all		14 aa 1.5 kDa	No	0
BRDT-012 ENSP00000400002 ENST00000427104	C9J1F7 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	155 aa 18.1 kDa	No	0
BRDT-013 ENSP00000410587 ENST00000448194	C9J1F7 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	155 aa 18.1 kDa	No	0
BRDT-016 ENSP00000414349 ENST00000450792	C9JLZ2 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	96 aa 11.3 kDa	No	0
BRDT-017 ENSP00000408138 ENST00000457265	C9JQ27 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all		32 aa 3.6 kDa	No	0
BRDT-019 ENSP00000447394 ENST00000548992	F8VZ63 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	100 aa 11.8 kDa	No	0
BRDT-020 ENSP00000446599 ENST00000552654	F8W0H2 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	63 aa 7.4 kDa	No	0
BRDT-201 ENSP00000378038 ENST00000394530	Q58F21 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0001207 [histone displacement] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006397 [mRNA processing] GO:0007140 [male meiosis] GO:0007141 [male meiosis I] GO:0007283 [spermatogenesis] GO:0008380 [RNA splicing] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0043484 [regulation of RNA splicing] GO:0051039 [positive regulation of transcription during meiosis] GO:0070577 [lysine-acetylated histone binding] Show all	901 aa 102.4 kDa	No	0
BRDT-202 ENSP00000387822 ENST00000399546	Q58F21 [Direct mapping] Bromodomain testis-specific protein Show all	Predicted intracellular proteins Show all	GO:0001207 [histone displacement] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006397 [mRNA processing] GO:0007140 [male meiosis] GO:0007141 [male meiosis I] GO:0007283 [spermatogenesis] GO:0008380 [RNA splicing] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0043484 [regulation of RNA splicing] GO:0051039 [positive regulation of transcription during meiosis] GO:0070577 [lysine-acetylated histone binding] Show all	951 aa 108.3 kDa	No	0

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