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BRDT

GENERAL INFORMATION

Gene name

 BRDT

Gene description

 Bromodomain, testis-specific

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression in spermatocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
CAB012237
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 BRDT (HGNC Symbol)

Synonyms

 BRD6, CT9

Description

 Bromodomain, testis-specific (HGNC Symbol)

Entrez gene summary

 BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

 1

Cytoband

 p22.1

Chromosome location (bp)

 91949371 - 92014426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137948 (version 83.38)

Entrez gene

 676

UniProt

 Q58F21 (UniProt - Evidence at protein level)

neXtProt

 NX_Q58F21

Antibodypedia

 BRDT antibodies

PROTEIN BROWSER
«
BRDT-001
BRDT-002
BRDT-003
BRDT-004
BRDT-005
BRDT-006
BRDT-007
BRDT-008
BRDT-012
BRDT-013
BRDT-016
BRDT-017
BRDT-019
BRDT-020
BRDT-201
BRDT-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRDT-001
ENSP00000354568
ENST00000362005
Q58F21 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
Show all
GO:0001207 [histone displacement]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007140 [male meiosis]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0008380 [RNA splicing]
GO:0030154 [cell differentiation]
GO:0042393 [histone binding]
GO:0043484 [regulation of RNA splicing]
GO:0051039 [positive regulation of transcription during meiosis]
GO:0070577 [lysine-acetylated histone binding]
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 947 aa
108 kDa 		No 0
BRDT-002
ENSP00000359416
ENST00000370389
Q58F21 [Direct mapping]
Bromodomain testis-specific protein
Show all
Predicted intracellular proteins
Show all
GO:0001207 [histone displacement]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007140 [male meiosis]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0008380 [RNA splicing]
GO:0030154 [cell differentiation]
GO:0042393 [histone binding]
GO:0043484 [regulation of RNA splicing]
GO:0051039 [positive regulation of transcription during meiosis]
GO:0070577 [lysine-acetylated histone binding]
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 874 aa
99.4 kDa 		No 0
BRDT-003
ENSP00000416714
ENST00000440509
C9JDL5 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 200 aa
22.8 kDa 		No 0
BRDT-004
ENSP00000396351
ENST00000423434
C9JD82 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 176 aa
20.4 kDa 		No 0
BRDT-005
ENSP00000404969
ENST00000426141
C9JJU3 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 462 aa
52.8 kDa 		No 0
BRDT-006
ENSP00000384051
ENST00000402388
Q58F21 [Direct mapping]
Bromodomain testis-specific protein
Show all
Predicted intracellular proteins
Show all
GO:0001207 [histone displacement]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007140 [male meiosis]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0008380 [RNA splicing]
GO:0030154 [cell differentiation]
GO:0042393 [histone binding]
GO:0043484 [regulation of RNA splicing]
GO:0051039 [positive regulation of transcription during meiosis]
GO:0070577 [lysine-acetylated histone binding]
Show all
 947 aa
108 kDa 		No 0
BRDT-007
ENSP00000408625
ENST00000449584
C9JMP1 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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 52 aa
6.1 kDa 		No 0
BRDT-008
ENSP00000400199
ENST00000355011
C9J0Z0 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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 14 aa
1.5 kDa 		No 0
BRDT-012
ENSP00000400002
ENST00000427104
C9J1F7 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 155 aa
18.1 kDa 		No 0
BRDT-013
ENSP00000410587
ENST00000448194
C9J1F7 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 155 aa
18.1 kDa 		No 0
BRDT-016
ENSP00000414349
ENST00000450792
C9JLZ2 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 96 aa
11.3 kDa 		No 0
BRDT-017
ENSP00000408138
ENST00000457265
C9JQ27 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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 32 aa
3.6 kDa 		No 0
BRDT-019
ENSP00000447394
ENST00000548992
F8VZ63 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 100 aa
11.8 kDa 		No 0
BRDT-020
ENSP00000446599
ENST00000552654
F8W0H2 [Direct mapping]
Bromodomain testis-specific protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 63 aa
7.4 kDa 		No 0
BRDT-201
ENSP00000378038
ENST00000394530
Q58F21 [Direct mapping]
Bromodomain testis-specific protein
Show all
Predicted intracellular proteins
Show all
GO:0001207 [histone displacement]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007140 [male meiosis]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0008380 [RNA splicing]
GO:0030154 [cell differentiation]
GO:0042393 [histone binding]
GO:0043484 [regulation of RNA splicing]
GO:0051039 [positive regulation of transcription during meiosis]
GO:0070577 [lysine-acetylated histone binding]
Show all
 901 aa
102.4 kDa 		No 0
BRDT-202
ENSP00000387822
ENST00000399546
Q58F21 [Direct mapping]
Bromodomain testis-specific protein
Show all
Predicted intracellular proteins
Show all
GO:0001207 [histone displacement]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007140 [male meiosis]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0008380 [RNA splicing]
GO:0030154 [cell differentiation]
GO:0042393 [histone binding]
GO:0043484 [regulation of RNA splicing]
GO:0051039 [positive regulation of transcription during meiosis]
GO:0070577 [lysine-acetylated histone binding]
Show all
 951 aa
108.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.