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RABGGTB

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GENERAL INFORMATION

Gene name

 RABGGTB

Gene description

 Rab geranylgeranyltransferase, beta subunit

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA026585
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA026585 A-431 Vesicles
HPA026585 U-2 OS Vesicles
HPA026585 U-251 MG Vesicles

GENE INFORMATION

Gene name

 RABGGTB

Synonyms

Description

 Rab geranylgeranyltransferase, beta subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 75786197 - 75795079

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137955 (version 83.38)

Entrez gene

 5876

UniProt

 P53611 (UniProt - Evidence at protein level)

neXtProt

 NX_P53611

Antibodypedia

 RABGGTB antibodies

PROTEIN BROWSER
RABGGTB-001
RABGGTB-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RABGGTB-001
ENSP00000317473
ENST00000319942
P53611 [Direct mapping]
Geranylgeranyl transferase type-2 subunit beta
Q6IB63 [Target identity:100%; Query identity:100%]
RABGGTB protein; Rab geranylgeranyltransferase, beta subunit, isoform CRA_d
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004663 [Rab geranylgeranyltransferase activity]
GO:0005515 [protein binding]
GO:0005968 [Rab-protein geranylgeranyltransferase complex]
GO:0006464 [cellular protein modification process]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0017137 [Rab GTPase binding]
GO:0018344 [protein geranylgeranylation]
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 331 aa
36.9 kDa 		No 0
RABGGTB-012
ENSP00000359862
ENST00000370826
Q5T4U8 [Direct mapping]
Geranylgeranyl transferase type-2 subunit beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 152 aa
17.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.