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Most cancer cells showed weak to moderate cytoplasmic staining. Cholangiocarcinomas, carcinoids and thyroid cancers showed moderate to strong cytoplasmic staining. Most cancers in the female genital tract and skin cancers were negative.
Most of the cancer cells displayed moderate to strong cytoplasmic positivity with additional membranous staining in a few cases. Most cases of melanomas, skin, lung and liver cancers showed weak cytoplasmic immunoreactivity or were negative.
This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]
Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)