Cell atlas - KHK - The Human Protein Atlas

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KHK

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	KHK
Gene description	Ketohexokinase (fructokinase)
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA007040
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007040	U-2 OS	Cytosol

GENE INFORMATION
Gene name	KHK
Synonyms
Description	Ketohexokinase (fructokinase) (HGNC Symbol)
Entrez gene summary	This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27086747 - 27100772
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138030 (version 83.38)
Entrez gene	3795
UniProt	P50053 (UniProt - Evidence at protein level)
neXtProt	NX_P50053
Antibodypedia	KHK antibodies

PROTEIN BROWSER

KHK-001	KHK-002	KHK-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KHK-001 ENSP00000260599 ENST00000260599	P50053 [Direct mapping] Ketohexokinase Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004454 [ketohexokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0009744 [response to sucrose] GO:0009749 [response to glucose] GO:0009750 [response to fructose] GO:0010043 [response to zinc ion] GO:0032868 [response to insulin] GO:0044281 [small molecule metabolic process] GO:0046835 [carbohydrate phosphorylation] GO:0061624 [fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate] GO:0070062 [extracellular exosome] GO:0070873 [regulation of glycogen metabolic process] Show all	298 aa 32.7 kDa	No	0
KHK-002 ENSP00000260598 ENST00000260598	P50053 [Direct mapping] Ketohexokinase Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004454 [ketohexokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0044281 [small molecule metabolic process] GO:0046835 [carbohydrate phosphorylation] GO:0061624 [fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate] GO:0070062 [extracellular exosome] Show all	298 aa 32.5 kDa	No	0
KHK-006 ENSP00000404741 ENST00000429697	C9JDL1 [Direct mapping] Ketohexokinase Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		279 aa 31 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.