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KHK

GENERAL INFORMATION

Gene name

 KHK

Gene description

 Ketohexokinase (fructokinase)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, renal cancer)
HPA (cell line):Cell line enhanced (Hep G2)
HPA (normal tissue):Group enriched (duodenum, kidney, liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression mainly in liver, small intestine and kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA007040
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007040

GENE INFORMATION

Gene name

 KHK

Synonyms

Description

 Ketohexokinase (fructokinase) (HGNC Symbol)

Entrez gene summary

 This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27086747 - 27100772

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138030 (version 83.38)

Entrez gene

 3795

UniProt

 P50053 (UniProt - Evidence at protein level)

neXtProt

 NX_P50053

Antibodypedia

 KHK antibodies

PROTEIN BROWSER
KHK-001
KHK-002
KHK-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KHK-001
ENSP00000260599
ENST00000260599
P50053 [Direct mapping]
Ketohexokinase
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004454 [ketohexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0009744 [response to sucrose]
GO:0009749 [response to glucose]
GO:0009750 [response to fructose]
GO:0010043 [response to zinc ion]
GO:0032868 [response to insulin]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061624 [fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate]
GO:0070062 [extracellular exosome]
GO:0070873 [regulation of glycogen metabolic process]
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 298 aa
32.7 kDa 		No 0
KHK-002
ENSP00000260598
ENST00000260598
P50053 [Direct mapping]
Ketohexokinase
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004454 [ketohexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061624 [fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate]
GO:0070062 [extracellular exosome]
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 298 aa
32.5 kDa 		No 0
KHK-006
ENSP00000404741
ENST00000429697
C9JDL1 [Direct mapping]
Ketohexokinase
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 279 aa
31 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.